Metabolism of Trigonelline

Metabolism of trigonelline.

During the germination of seeds and the early growth of plants, trigonelline (N-methylnicotinic acid) disappears and pyridine nucleotides appear in the plant tissue (1, 2). Hence, it has been surmised, albeit without direct evidence, that the trigonelline of the seeds is a precursor of pyridine nucleotides in seedling plants. In an earlier study from this laboratory (3), it was shown that prepa...

Biosynthesis of trigonelline.

Trigonelline, N-methyl nicotinic acid, was first noted in the seeds of Trigonella joenum-graecum (the fenugreek) (1) and has since been found in the seeds and tubers of many species (2,3) as well as in leaves of one species of pea (4). Although one may assume that trigonelline arises metabolically from nicotinic acid, definitive evidence has been lacking. In the course of several attempts to de...

Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy

The mechanisms leading to diabetic peripheral neuropathy are complex and there is no effective drug to treat it. As an active component of several traditional Chinese medicines, trigonelline has beneficial effects on diabetes with hyperlipidemia. The protective effects and the mechanism of trigonelline on diabetic peripheral neuropathy were evaluated in streptozotocin- and high-carbohydrate/hig...

Insights into the Effect of Trigonelline in the P53 Pathway

Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds.

Changes in trigonelline content and in biosynthetic activity were determined in the cotyledons and embryonic axes of etiolated mungbean (Phaseolus aureus) seedlings during germination. Accumulation of trigonelline (c. 240 nmol per pair of cotyledons) was observed in the cotyledons of dry seeds; trigonelline content decreased 2 d after imbibition. Trigonelline content in the embryonic axes incre...